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In RDS, the most impor-tant shunt is intrapulmonary, as capillary bloodtravels through unventilated, or hypoventilated,atelectatic areas of the lung. Moreover, in addition to suppressing Mdm2-mediated effects on p53, ARF modulate the activity of other E3 ligases such asARF-BP1 and ARF/ARF-BP1 interaction was found to be involved in bothp53-dependent and p53-independent functions of ARF [52]

Moreover, in addition to suppressing Mdm2-mediated effects on p53, ARF modulate the activity of other E3 ligases such asARF-BP1 and ARF/ARF-BP1 interaction was found to be involved in bothp53-dependent and p53-independent functions of ARF [52]. Antioxidant response of osteoblasts to doxycycline in aninflammatory model induced by C-reactive protein and interleukin-6.

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